7 DRUG INTERACTIONS
Food and Drug Administration.
What is Sildenafil Citrate?
SILDENAFIL CITRATE- sildenafil citrate tablet, film coated Greenstone LLC What is the most important information I should know about SILDENAFIL CITRATE TABLETS? SILDENAFIL CITRATE TABLETS can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. Do not take SILDENAFIL CITRATE TABLETS if you take any other medicines called "nitrates." Nitrates are used to treat chest pain (angina). A sudden drop in blood pressure can cause you to feel dizzy, faint, or have a heart attack or stroke. Do not take SILDENAFIL CITRATE TABLETS if you take medicines called guanylate cyclase stimulators which include: Riociguat (Adempas®) a medicine that treats pulmonary arterial hypertension and chronic-thromboembolic pulmonary hypertension.
Seek Immediate Medical Help If You Experience:
Tell all your healthcare providers that you take SILDENAFIL CITRATE TABLETS. If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took SILDENAFIL CITRATE TABLETS. Ask your doctor if your heart is healthy enough to handle the extra strain of having sex. SILDENAFIL CITRATE TABLETS does not protect you or your partner from getting sexually transmitted diseases, including HIV—the virus that causes AIDS. SILDENAFIL CITRATE TABLETS is a prescription medicine used to treat erectile dysfunction (ED).
How can I get Viagra to work?
You will not get an erection just by taking this medicine. SILDENAFIL CITRATE TABLETS helps a man with erectile dysfunction get and keep an erection only when he is sexually excited (stimulated). SILDENAFIL CITRATE TABLETS is not for use in women or children. It is not known if SILDENAFIL CITRATE TABLETS is safe and effective in women or children under 18 years of age. Who should not take SILDENAFIL CITRATE TABLETS? This product's label may have been updated.
- Sildenafil citrate was originally developed for hypertension.
- It was later approved for erectile dysfunction treatment.
- Brand names include Viagra and Revatio.
For current full prescribing information, please visit Cardura (doxazosin mesylate), and Minipress (prazosin HCl) are registered trademarks of Pfizer Inc.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 150mg | 270 + 10 Pills | 326.61€ 311.06€ | |
| Viagra Generic | 25mg | 180 + 6 Pills | 154.93€ 147.55€ | |
| Viagra Generic | 200mg | 180 + 10 Pills | 277.56€ 264.34€ | |
| Viagra Generic | 25mg | 60 + 4 Pills | 71.99€ 68.56€ | |
| Kamagra Oral Jelly | 100mg | 63 + 7 Sachets | 224.18€ 213.50€ | |
| Viagra Generic | 200mg | 60 + 4 Pills | 125.19€ 119.23€ | |
| Kamagra | 100mg | 32 Pills | 121.24€ 115.47€ | |
| Viagra Generic | 25mg | 30 + 4 Pills | 47.97€ 45.69€ | |
| Viagra Generic | 150mg | 20 Pills | 55.02€ 52.40€ | |
| Viagra Generic | 25mg | 10 Pills | 25.19€ 23.99€ | |
| Kamagra | 100mg | 20 Pills | 86.09€ 81.99€ | |
| Viagra Generic | 150mg | 180 + 10 Pills | 236.46€ 225.20€ | |
| Viagra Generic | 200mg | 30 + 2 Pills | 83.07€ 79.11€ | |
| Viagra Generic | 200mg | 20 Pills | 61.69€ 58.75€ | |
| Kamagra Soft Tabs | 100mg | 12 Pills | 57.55€ 54.81€ | |
| Viagra Generic | 50mg | 120 + 6 Pills | 129.64€ 123.47€ | |
| Viagra Generic | 100mg | 180 + 8 Pills | 199.37€ 189.88€ |
The other brands listed are trademarks of their respective owners and are not trademarks of Pfizer Inc. The makers of these brands are not affiliated with and do not endorse Pfizer Inc or its products. A complete guide to L-arginine for erections Let's delve into the science behind L-arginine’s ability to improve erectile function - and examine just how effective it is.
Renal Dose Adjustments
These are not all the possible side effects of SILDENAFIL CITRATE TABLETS. For more information, ask your healthcare provider or pharmacist. You may report side effects to FDA at 1-800-FDA-1088. How should I store SILDENAFIL CITRATE TABLETS? Store SILDENAFIL CITRATE TABLETS at room temperature between 68°F to 77°F (20°C to 25°C).
Serious Side Effects
Keep SILDENAFIL CITRATE TABLETS and all medicines out of the reach of children. General information about the safe and effective use of SILDENAFIL CITRATE TABLETS. Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use SILDENAFIL CITRATE TABLETS for a condition for which it was not prescribed. Do not give SILDENAFIL CITRATE TABLETS to other people, even if they have the sildenafil white same symptoms that you have. To ensure you’re getting the best results from sildenafil, you should make sure that you’re using it correctly and safely. Below we have detailed the answers to some of the most commonly asked questions about taking sildenafil correctly.
| Condition | Risk | Recommendations |
|---|---|---|
| Concomitant Nitrate Use | Severe hypotension | Avoid combination |
| Cardiac Conditions | Risk of myocardial infarction or arrhythmia | Consult cardiologist |
| Severe Liver Impairment | Altered drug metabolism | Dose adjustment needed |
| Hypotension (low BP) | Further blood pressure reduction | Use with caution |
If you want to find out about the possible side effects of sildenafil, you can find a separate article about that here. Sildenafil is a medication used to treat erectile dysfunction which is effective and generally well-tolerated.
2.3 Dosage Adjustments in Specific Situations
This Patient Information leaflet summarizes the most important information about SILDENAFIL CITRATE TABLETS. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about SILDENAFIL CITRATE TABLETS that is written for health professionals. For more information, go to or call 1-800-438-1985 What are the ingredients in SILDENAFIL CITRATE TABLETS? This Patient Information has been approved by the U.S. There are a few potential side effects to be aware of, including headaches, nausea, and dizziness.
5.5 Hypotension when Co-administered with Alpha-blockers or Anti-hypertensives
Take SILDENAFIL CITRATE TABLETS about 1 hour before sexual activity. You may take SILDENAFIL CITRATE TABLETS between 30 minutes to 4 hours before sexual activity if needed. SILDENAFIL CITRATE TABLETS can be taken with or without food. If you take SILDENAFIL CITRATE TABLETS after a high fat meal (such as a cheeseburger and french fries), SILDENAFIL CITRATE TABLETS may take a little longer to start working Do not take SILDENAFIL CITRATE TABLETS more than 1 time a day. If you accidentally take too much SILDENAFIL CITRATE TABLETS, call your doctor or go to the nearest hospital emergency room right away.
What happens with ED?
What are the possible side effects of SILDENAFIL CITRATE TABLETS? SILDENAFIL CITRATE TABLETS can sildenafil 100mg blue pill cause serious side effects. an erection that will not go away (priapism). sudden vision loss in one or both eyes. It is uncertain whether PDE5 inhibitors directly cause the vision loss.
Common Adverse Effects
Stop taking SILDENAFIL CITRATE TABLETS and call your healthcare provider right away if you have sudden vision loss in one or both eyes. If you have these symptoms, stop taking SILDENAFIL CITRATE TABLETS and contact a doctor right away. The most common side effects of SILDENAFIL CITRATE TABLETS are: abnormal vision, such as changes in color vision (such as having a blue color tinge) and blurred vision In addition, heart attack, stroke, irregular heartbeats and death have happened rarely in men taking SILDENAFIL CITRATE TABLETS. Most, but not all, of these men had heart problems before taking SILDENAFIL CITRATE TABLETS. It is not known if SILDENAFIL CITRATE TABLETS caused these problems. These are fairly uncommon, but if you are struggling with them you should speak to your clinician.
| Property | Description | Value | Notes |
|---|---|---|---|
| Molecular Formula | C22H30N6O4S | ||
| Molecular Weight | 474.58 g/mol | ||
| Melting Point | 189-192°C | ||
| Solubility in Water | Slightly soluble | at 25°C | |
| pH Range | 3.8 - 4.0 | in aqueous solution |
But like any other medication, it needs to be taken exactly as your doctor or pharmacist has instructed.
Detection in biological fluids
Do not take SILDENAFIL CITRATE TABLETS if you: take medicines called nitrates (such as nitroglycerin) use street drugs called "poppers" such as amyl nitrate or amyl nitrite, and butyl nitrate take any medicines called guanylate cyclase stimulators such as riociguat (Adempas) are allergic to sildenafil, as contained in SILDENAFIL CITRATE TABLETS and REVATIO, or any of the ingredients in SILDENAFIL CITRATE TABLETS. See the end of this leaflet for a complete list of ingredients in SILDENAFIL CITRATE TABLETS. What should I tell my healthcare provider before taking SILDENAFIL CITRATE TABLETS? Before you take SILDENAFIL CITRATE TABLETS, tell your healthcare provider if you: have or have had heart problems such as a heart attack, irregular heartbeat, angina, chest pain, narrowing of the aortic valve or heart failure have had heart surgery within the last 6 months have low blood pressure, or high blood pressure that is not controlled have had an erection that lasted for more than 4 hours have problems with your blood cells such as sickle cell anemia, multiple myeloma, or leukemia have retinitis pigmentosa, a rare genetic (runs in families) eye disease have ever had severe vision loss, including an eye problem called non-arteritic anterior ischemic optic neuropathy (NAION) have kidney problems or are having kidney dialysis Tell your healthcare provider about all the medicines you take1, including prescription and over-the-counter medicines, vitamins, and herbal supplements. SILDENAFIL CITRATE TABLETS may affect the way other medicines work, and other medicines may affect the way SILDENAFIL CITRATE TABLETS works causing side effects.
What causes an erection?
Especially tell your healthcare provider if you take any of the liquid sildenafil citrate following: medicines called nitrates (see "What is the most important information I should know about SILDENAFIL CITRATE TABLETS?") medicines called guanylate cyclase stimulators, such as riociguat (Adempas) medicines called alpha blockers such as Hytrin (terazosin HCl), Flomax (tamsulosin HCl), Cardura (doxazosin mesylate), Minipress (prazosin HCl), Uroxatral (alfuzosin HCl), Jalyn (dutasteride and tamsulosin HCl), or Rapaflo (silodosin). Alpha-blockers are sometimes prescribed for prostate problems or high blood pressure. In some patients, the use of SILDENAFIL CITRATE TABLETS with alpha-blockers can lead to a drop in blood pressure or to fainting. medicines called HIV protease inhibitors, such as ritonavir (Norvir), indinavir sulfate (Crixivan), saquinavir (Fortovase or Invirase) or atazanavir sulfate (Reyataz) some types of oral antifungal medicines, such as ketoconazole (Nizoral), and itraconazole (Sporanox) some types of antibiotics, such as clarithromycin (Biaxin), telithromycin (Ketek), or erythromycin other medicines that treat high blood pressure SILDENAFIL CITRATE TABLETS contains sildenafil, which is the same medicine found in another drug called SILDENAFIL TABLETS. SILDENAFIL TABLETS is used to treat a rare disease called pulmonary arterial hypertension (PAH).
Pulmonary hypertension
SILDENAFIL CITRATE TABLETS should not be used with SILDENAFIL TABLETS or with other PAH treatments containing sildenafil or any other PDE5 inhibitors (such as Adcirca [tadalafil]). Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure. How should I take SILDENAFIL CITRATE TABLETS? Take SILDENAFIL CITRATE TABLETS exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much SILDENAFIL CITRATE TABLETS to take and when to take it. Sildenafil works by allowing your arteries to relax and open, by making more of a chemical called cGMP available.
| Common Side Effect | Frequency | Severity | Notes |
|---|---|---|---|
| Headache | Very common | Mild to moderate | Usually transient |
| Flushing | Common | Mild | Often resolves quickly |
| Dyspepsia / Indigestion | Common | Mild | Can be managed with antacids |
| Visual Disturbances | Less common | Mild | Changes in color perception |
| Priapism | Rare | Serious | Medical emergency, requires immediate attention |
Increasing blood flow through the arteries in the penis means improved erectile function. Cells in your arteries normally release nitric oxide, which, via molecular messengers including cGMP, sends instructions to muscle proteins to relax.
- The onset of action is usually within 30 minutes.
- Peak effect occurs around 1 hour after ingestion.
- The duration of action can last up to 4-6 hours.
This causes increased blood flow into your penis, which causes an erection. An enzyme called PDE-5 normally breaks down that cGMP, which reverses that relaxation, allowing your erection to subside.
- Common side effects include headache and flushing.
- Some may experience nasal congestion or dizziness.
- Serious side effects require immediate medical attention.